Effects of metformin on cell kinetic parameters of MCF-7 breast cancer cells in vitro.
نویسندگان
چکیده
In this study, the antiproliferative effects of the metformin was evaluated on MCF-7 Cells (human breast adenocarcinoma cell line). For this purpose cell kinetic parameters including cell proliferation assay, mitotic index and labelling index analysis were used. 30 μM, 65 μM and 130 μM Metformin doses were applied to cells for 24, 48 and 72 hours. The results showed that there was a significant decrease in cell proliferation, mitotic index and labelling index for all experimental groups (p<0.05) for all applications.
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ورودعنوان ژورنال:
- Asian Pacific journal of cancer prevention : APJCP
دوره 16 6 شماره
صفحات -
تاریخ انتشار 2015